Tuesday, December 25, 2012

J.R. Smith Threw Down a Crazy Dunk Over Greg Stiemsma (VIDEO)

By Chris Yuscavage, Complex Sports

The title that the NBA gave to this video on their YouTube page sums it up perfectly.

"J.R. Smith Serves Up the Nasty."

Yup, sounds about right.

WATCH VIDEO ABOVE

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Source: http://www.huffingtonpost.com/2012/12/24/jr-smith-greg-stiemsma-dunk-knicks-timberwolves_n_2359663.html

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How To Structure An Online Joint Venture For ... - Name.com

HOW TO STRUCTURE AN ONLINE JOINT VENTURE FOR MAXIMUM BENEFIT

When you are getting started online, one of the first things that you need to build is a customer base. ?Of course, that is difficult to do if you are new and no one knows about you or your products. ?To overcome this you will have to grow your following using SEO, PR and social media.

However, one thing that you can do to jump start the building of your customer base is to leverage the following of someone who has already established themselves in the niche you are entering. ?Many online marketers have participated in?a joint venture?with a marketer who has already developed his?own customer base and seen impressive results.

In a joint venture you are working with another marketer to create and deliver a new product for the marketplace. ?This works well for new marketers when they have an innovative product or service to sell to the niche, but do not necessarily have a solid customer base. Therefore the established marketer is lending her?name, market power and customer database to the project.

When you are looking for potential joint venture partners, a prudent way to make your case to them?is to purchase their product (if possible). ?This will typically give you contact information that the established marketer doesn?t share with non business partners. ?Another factor to keep in mind is that these individuals will have likely received joint venture requests before yours. ?Most of the requests they receive will be hastily crafted emails, which the marketer will find easy to turn down. ?Your approach should be different (consider sending a letter instead of an email) and professional, so that it stands out from the rest.

To create a well run joint venture, the parties typically set up a formal agreement?of some kind once they have decided on the various responsibilities they need to take to bring their product to market. ?When you are first starting, it is typical to accept less than 50% of the profits, as well as doing more than 50% of the work. ?The joint venture benefits you a great deal because not only will you be gaining new customers, but you will also be building your customer database.

Categories: startmybiz | Permalink

Source: http://www.name.com/blog/startmybiz/2012/12/how-to-structure-an-online-joint-venture-for-maximum-benefit/

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What Are the Symptoms of Uterine Cancer? | Cervical dysplasia ...

Cancer is one of the most dreaded diseases in the world. The body cells start functioning in an abnormal way in the person suffering from cancer and the tumors are formed in the affected area of the body. Breast, ovarian, cervical and uterine cancers are those types of cancers that target only the women as these are related to the female body organs.

If we talk about the uterine cancer, it is in fact related to the very important organ of the female reproductive system called the uterus and usually occurs in the women between the ages of 50 to 70 years. This cancer has different types including uterine sarcomas, endometrial cancer and cervical cancer. Each type affects different parts and tissues of the female uterus e.g. endometrial cancer (also called endometrial carcinoma) is related to the uterus lining or endometrium. The uterine sarcoma (also called leiomyosarcomas) affects the muscular layer of the uterus and cervical cancer is related to the lower portion of the uterus.

Among these types, the endometrial cancer is one that is generally referred to as the uterine cancer. The endometrial cancer is so deadly that it is believed to be the third most common gynecologic cancer (after ovarian and cervical cancers) that causes death to the women.

This cancer usually affects the women after the occurrence of the menopause (the phase in a woman?s life when menstrual cycle gets stopped). There are some common symptoms of this cancer though these may differ to some extent from person to person.

The most general symptom of this cancer in a woman is the abnormal vaginal bleeding even after her menopause. However the excessive menstrual bleeding in a woman in her premenopausal period shouldn?t be ignored too. The other symptoms include the unusual non-bloody vaginal discharge, lower abdominal pain, abnormal weight loss, difficult and painful urination and an extreme pain during intercourse.

Every woman is needed to know about the basic symptoms of the uterine cancer so that if she finds any of them in herself, she may urgently contact her physician. The importance of seeking the timely medical advice after finding some of these symptoms is very high as it may help to diagnose the uterine cancer at some early stage and you must know that this cancer can be treated effectively at the early stages. Besides, if the endometrial cancer is diagnosed after the full medical check up of a woman, the proper measure can be taken at the right time in order to avoid further complications.

Learn more about health information, please visit the useful site of Shields Comptois: http://www.megaarticle.com/category/health/

Cancer, Symptoms, Uterine

Source: http://cervicaldysplasia.healthrisks.biz/what-are-the-symptoms-of-uterine-cancer-2/

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Source: http://idivyputa.posterous.com/what-are-the-symptoms-of-uterine-cancer-cervi

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Source: http://sigiueeo.posterous.com/what-are-the-symptoms-of-uterine-cancer-cervi

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Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children

Dec. 23, 2012 ? Acute lymphatic leukemia (ALL) is the most common cancer in children under the age of 14 years. With optimum treatment, approximately 75 percent of children are currently cured, but the treatment consists of severe chemotherapy with many side effects. In collaboration with international research teams, scientists at VIB, KU Leuven and UZ Leuven have identified new genetic mutations that lead to T-ALL, a variant of ALL. They have unmasked the ribosome -- the molecular machine in the cell that is involved in the production of proteins -- as a weak spot in leukemia cells.

Their research has also shown that there is a difference in T-ALL between adults and children. Both findings can be important in the search for improved treatments for T-ALL.

Jan Cools (VIB/KU Leuven): "We have discovered that there is a clear genetic difference between T-ALL in children and in adults. This could be an explanation why adults do not respond as well to the current therapy."

Stein Aerts (KU Leuven): "This is a beautiful example of the power of genome sequencing in cancer research. New technologies and large-scale bio-informatics allow us to study a lot of data simultaneously. This allows us to discover links that would have been impossible to find in the past."

T-cell acute lymphatic leukemia (T-ALL)

The formation of white blood cells is disrupted by leukemia. The cells in the bone marrow that should mature into white blood cells multiply unchecked without maturing completely. These immature blood cells compromise the production of normal blood cells. This makes patients more susceptible to infections. Leukemia occurs in different forms; in the case of T-ALL, there is an accumulation of immature white blood cells over a very short period of time. With optimum treatment -- involving chemotherapy -- approximately 75 % of children are currently cured. For adults, the chance of a cure is below 50 %. Chemotherapy is associated with many side effects. The search for a more specific treatment can only start once we know what causes T-ALL.

7 new genes with a key role in T-ALL identified

T-ALL only occurs if errors in various genes occur simultaneously. It is important to determine which genes play a key role. Kim De Keersmaecker, Zeynep Kalender Atak, Jan Cools and Stein Aerts have identified a series of defects in 15 important genes, of which 7 have not previously been associated with T-ALL. They used next-generation sequencing to analyze the 20,000+ genes of 67 T-ALL patients. This technique allows for very fast analysis and comparison of the complete DNA sequence of healthy and sick individuals.

A difference between adults and children

The investigators from Leuven also discovered a difference between T-ALL in children and in adults. T-ALL in adults contains significantly more mutations than in children. The leukemia cells in adults also contain mutations in other genes than in children. This genetic difference could be a possible explanation why adults do not respond as well to the current therapy.

A weak point in leukemia cells exposed

RPL5 and RPL10 -- two newly identified genes -- form part of the ribosome: this is the complex in the cell that produces proteins. The scientists hereby demonstrated for the first time that defects in the ribosome can also play a role in cancer activation. Experiments in yeast cells confirm that mutations in RPL10 cause a change in the ribosome.

Kim De Keersmaecker (VIB/KU Leuven): "This could be a weak point of the leukemia cells: all cells need properly functioning ribosomes to survive and to grow. These 'defective' ribosomes in the leukemia cells could be a new suitable target for the development of targeted therapies."

Patient information

As this study may raise many questions in patients, we would like to refer you to the e-mail address that the VIB has set up for this purpose. Anyone with questions about this research and other medical research can submit their questions on patients@vib.be. Please submit your question in Dutch or English only.

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Story Source:

The above story is reprinted from materials provided by VIB, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Kim De Keersmaecker, Zeynep Kalender Atak, Ning Li, Carmen Vicente, Stephanie Patchett, Tiziana Girardi, Valentina Gianfelici, Ellen Geerdens, Emmanuelle Clappier, Micha?l Porcu, Idoya Lahortiga, Rossella Luc?, Jiekun Yan, Gert Hulselmans, Hilde Vranckx, Roel Vandepoel, Bram Sweron, Kris Jacobs, Nicole Mentens, Iwona Wlodarska, Barbara Cauwelier, Jacqueline Cloos, Jean Soulier, Anne Uyttebroeck, Claudia Bagni, Bassem A Hassan, Peter Vandenberghe, Arlen W Johnson, Stein Aerts, Jan Cools. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genetics, 2012; DOI: 10.1038/ng.2508

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/t1aTr52MtSw/121223152437.htm

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Monday, December 24, 2012

Gunman who ambushed firefighters killed grandma in '80

Webster Police Chief Gerald Pickering says the gunman, who he identified as William Spengler, was a convicted felon who served 17 years in prison for killing his grandmother more than three decades ago.

By Jason White, NBC News

Monroe County Sheriff's Office

Undated booking photo of William Spengler, who shot and killed two firefighters Monday.

The gunman who ambushed four volunteer firefighters, killing two, in upstate New York had spent 17 years in prison for beating his grandmother to death with a hammer in 1980, police said.

William Spengler opened fire on the volunteers as they responded to a blaze just before 6 a.m. ET in a small cluster of homes along Lake Ontario in Webster, N.Y., police said, rocking this close-knit community.

The 62-year-old convicted felon had apparently set a trap, luring in first responders and then firing on them from atop an earthen berm.

"It does appear that it was a trap that was set,"?said Webster Police Chief Gerald Pickering,?his voice breaking at times.??People who get up in the middle of the night to fight fires, they don?t expect to get shot and killed."


Pickering lost a colleague in the incident: Police Lieutenant?Michael Chiapperini, who was a volunteer firefighter. The other firefighter killed by Spengler was?Tomasz Kaczowka.

Despite being shot, one of the injured firefighters was able to flee from scene under his own power. But the others remained pinned down on the narrow strip of land between Lake Ontario and Irondequoit Bay until a SWAT team arrived.

Webster Police Lt. Michael Chiapperini.

As police closed in, Spengler took his own life with a gunshot wound to the head, Pickering said. He was convicted of manslaughter in 1981 after the death of his grandmother, Rose Spengler, and was paroled in 1998.

Spengler's 67-year-old sister Cheryl Spengler is unaccounted for, Pickering said. Spengler lived in the house with his sister and mother, Arline, who died in October.

Prior to Monday's shooting, Webster police had not had any run-ins with Spengler since he was paroled, they said.

Police would not say what kinds of guns Spengler used, but as a convicted felon, he could not legally own firearms.

Firefighter Tomasz Kaczowka in an undated photo.

The two injured firefighters, Theodore Scardino and?Joseph Hofstetter,?were being treated for "significant injuries," according to Dr. Nicole Stassen, a surgeon at the?University of Rochester Medical Center. She said both were awake and alert and not on ventilators.

An off-duty police officer was also injured when he was hit by shrapnel after his car took bullets to the windshield and engine block, according to the?Rochester Democrat and Chronicle. His condition is unclear at this time.

After the shooting, the fire grew to engulf at seven homes and one motor vehicle.?

?These firemen are part of our family. You go into a fire with these guys. To see them go down with something like this is totally unexpected. We are in shock,? Billy Gross, fire commissioner for West Webster, told the?Democrat and Chronicle.

Dozens of area residents were evacuated, with police searching them as they left, the newspaper reported.

"Miserable thing to happen this time of year," Mark Johns, a state assemblyman who represents the area, told?local NBC station WHEC. Johns said he knew some of the firefighters who were shot.

New York Gov. Andrew Cuomo issued a statement after the shooting, offering his "deepest condolences."

?All of our thoughts and prayers go to the families and friends of those who were killed in this senseless act of violence," Cuomo said.??New York's first responders are true heroes as they time and again selflessly rush toward danger in order to keep our families and communities safe."

NBC's Tom Winter and Rosanna Arlia contributed to this report.

Investigators say the firefighters were ambushed and shot while responding to a fire in West Webster, N.Y., a suburb of Rochester. NBC's Chris Pollone reports.

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Source: http://usnews.nbcnews.com/_news/2012/12/24/16125861-gunman-who-ambushed-firefighters-killed-grandmother-in-1980-police-say?lite

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Sunday, December 23, 2012

Hawaii part of national debt relief fees settlement | Hawaii 24/7

MEDIA RELEASE

The Department of Commerce and Consumer Affairs (DCCA) through the Office of Consumer Protection (OCP) announced that it has partnered with the U.S. Consumer Financial Protection Bureau (CFPB) and four other states in the CFPB?s first joint enforcement action against a nationwide debt-relief services company that illegally charged advance fees for its services.

A federal district court in Miami has issued an order at the request of the CFPB and the five states requiring that Payday Loan Debt Solutions, Inc. (PLDS) refund up to $100,000 to consumers who were unlawfully charged advance fees for debt-settlement services.

The court also granted an injunction barring PLDS and its president, Sanjeet Parvani, from engaging in unlawful conduct in the future.

PLDS allegedly contacted Hawaii residents through the Internet offering to reduce or eliminate payday loans owed by Hawaii residents and then charged them upfront fees before settling their loans.

?This case reaffirms that for-profit companies are barred from conducting debt-adjusting or debt-settlement services under Hawaii law. Generally, only nonprofit credit-counseling companies or attorneys licensed to practice law in Hawaii can perform such services,? OCP Executive Director Bruce Kim said.

If Hawaii residents made advance payments to this company, OCP recommends that they contact PLDS immediately and request a refund of any outstanding balances believed to be in their accounts.

?Everyone is urged to use extreme caution if contacted online, by telephone or through the mail by anyone offering to settle, compromise or reduce your debts. Residents are also reminded that it is generally illegal under federal law for anyone to charge an up-front fee before attempting to settle your debts,? Kim said.

OCP is pleased to join CFPB Director Richard Cordray and the CFPB in the first joint enforcement action between the CFPB and the states. The Office of Consumer Protection looks forward to working together with the CFPB in future consumer protection cases of mutual interest.

Hawaii was represented by Lisa Tong, a senior staff attorney in the Office of Consumer Protection.

Source: http://www.hawaii247.com/2012/12/22/hawaii-part-of-national-debt-relief-fees-settlement/

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Obama calls for smaller-scale budget deal with GOP

President Barack Obama and first lady Michelle Obama wave as they board Air Force One at Andrews Air Force Base, Md., Friday, Dec. 21, 2012 before departing for Hawaii. (AP Photo/Ann Heisenfelt)

President Barack Obama and first lady Michelle Obama wave as they board Air Force One at Andrews Air Force Base, Md., Friday, Dec. 21, 2012 before departing for Hawaii. (AP Photo/Ann Heisenfelt)

Speaker of the House John Boehner, R-Ohio, speaks to reporters about the fiscal cliff negotiations at the Capitol in Washington, Friday, Dec. 21, 2012. Hopes for avoiding the "fiscal cliff" that threatens the U.S. economy fell Friday after fighting among congressional Republicans cast doubt on whether any deal reached with President Barack Obama could win approval ahead of automatic tax increases and deep spending cuts kick in Jan. 1. (AP Photo/J. Scott Applewhite)

(AP) ? President Barack Obama has throttled back his ambitions for a sweeping budget bargain with Republicans. Instead, he's calling for a scaled-back measure sufficient to prevent the government from careening off the "fiscal cliff" in January by extending tax cuts for most taxpayers and forestalling a painful set of agency budget cuts.

In a White House appearance Friday, Obama also called on Congress to extend jobless benefits for the long-term unemployed that would otherwise be cut off for 2 million people at the end of the year.

Obama's announcement was a recognition that chances for a larger agreement before year's end have probably collapsed. It also suggested that any chance for a smaller deal may rest in the Senate, particularly after the collapse of a plan by House Speaker John Boehner, R-Ohio, to permit tax rates to rise on million-dollar-plus incomes.

"In the next few days, I've asked leaders of Congress to work towards a package that prevents a tax hike on middle-class Americans, protects unemployment insurance for 2 million Americans, and lays the groundwork for further work on both growth and deficit reduction," Obama said. "That's an achievable goal. That can get done in 10 days."

Maybe, maybe not. The latest plan faces uncertainty at best in the sharply divided Senate. GOP leader Mitch McConnell of Kentucky, who wields great power even in the minority, called Friday for Senate action on a House bill from the summer extending the full menu of Bush-era tax cuts. He promised that it will take GOP votes for anything to clear the Senate, where 60 votes are required to advance most legislation. Democrats control 53 votes.

Earlier, Boehner said Obama needs to give more ground to reach an agreement and that both he and Obama had indicated in a Monday telephone call that their latest offers represented their bottom lines. "How we get there," he added, "God only knows."

Congress shut down for Christmas and Obama flew to Hawaii with his family for the holidays. But both men indicated they'd be back in Washington, working to beat the fast-approaching Jan. 1 deadline with an agreement between Christmas and New Year's.

Obama announced his plans after talking by phone with Boehner and meeting with Senate Majority Leader Harry Reid, D-Nev., who had previously pinned his hopes on an Obama-Boehner agreement and is wary of dealing with McConnell.

At the White House, Obama projected optimism despite of weeks of failed negotiations. "Call me a hopeless optimist, but I actually still think we can get it done," he said.

Boehner spoke in the morning, describing the increasingly tangled attempts to beat the Jan. 1 deadline and head off the perilous combination of across-the-board tax hikes and deep spending cuts.

"Because of the political divide in the country, because of the divide here in Washington, trying to bridge these differences has been difficult," Boehner said. "If it were easy, I guarantee you this would have been done decades before."

Obama said that in his negotiations with Boehner, he had offered to meet Republicans halfway when it came to taxes and "more than halfway" toward their target for spending cuts.

It's clear, however, that there's great resistance in GOP ranks to forging a bargain with Obama along the lines of a possible agreement that almost seemed at hand just a few days ago: tax hikes at or just over $1 trillion over 10 years, matched by comparable cuts to federal health care programs, Social Security benefits and across federal agency operating budgets.

Obama said he remains committed to working toward a goal of longer-term deficit reduction to reduce chronic trillion-dollar deficits while keeping tax rates in place for nearly everyone.

"Even though Democrats and Republicans are arguing about whether those rates should go up for the wealthiest individuals, all of us ? every single one of us ? agrees that tax rates shouldn't go up for the other 98 percent of Americans," Obama said, citing statistics associated with his promise to protect household income under $250,000 from higher tax rates.

Neither the House nor the Senate is expected to meet again until after Christmas. Officials in both parties said there was still time to prevent the changes from kicking in with the new year.

The week began amid optimism that Obama and Boehner had finally begun to significantly narrow their differences. Both were offering a cut in taxes for most Americans, an increase for a relative few, and cuts of roughly $1 trillion in spending over a year. Also included was a provision to scale back future cost-of-living increases for Social Security recipients ? a concession by the president that inflamed many liberals..

GOP officials said some senior Republicans such as Rep. Paul Ryan, R-Wis., the most recent Republican vice presidential nominee, opposed the possible agreement. But No. 2 House Republican Eric Cantor of Virginia has joined arms with Boehner.

Boehner stepped back and announced what he called Plan B, legislation to let tax rates rise on incomes of $1 million or more while preventing increases for all other taxpayers.

Despite statements of confidence, he and his lieutenants decided late Thursday they were not going to be able to secure the votes needed to pass the measure in the face of opposition from conservatives unwilling to violate decades-old party orthodoxy never to raise tax rates.

The retreat came after it became clear that too many Republicans feared "the perception that somebody might accuse them of raising taxes," Boehner said.

Boehner also said that last Monday he had told Obama he had submitted his bottom-line proposal.

"The president told me that his numbers ? the $1.3 trillion in new revenues, $850 billion in spending cuts ? was his bottom line, that he couldn't go any further."

That contradicted remarks by White House press secretary Jay Carney, who said on Thursday that Obama has "never said either in private or in public that this was his final offer. He understands that to reach a deal it would require some further negotiation. There is not much further he could go."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-12-22-Fiscal%20Cliff/id-16a5d47029564ca6a84c1b7edde3bbfa

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